Genetic Variation of VKORC1 and CYP4F2 Genes Related to Warfarin Maintenance Dose in Patients with Myocardial Infarction
Joint Authors
Kringen, Marianne K.
Grimholt, Runa M.
Haug, Kari Bente Foss
Brørs, Odd
Berg, Jens Petter
Stormo, Camilla
Fosen, Jan Toralf
Piehler, Armin P.
Opdal, Mimi S.
Narum, Sigrid
Johansen, Per W.
Seljeflot, Ingebjørg
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of this study was to investigate whether the VKORC1*3 (rs7294/9041 G > A), VKORC1*4 (rs17708472/6009 C > T), and CYP4F2 (rs2108622/1347 C > T) polymorphisms were associated with elevated warfarin maintenance dose requirements in patients with myocardial infarction (n=105) from the Warfarin Aspirin Reinfarction Study (WARIS-II).
We found significant associations between elevated warfarin dose requirements and VKORC1*3 and VKORC1*4 polymorphisms (P=.001 and P=.004, resp.), whereas CYP4F2 (1347 C > T) showed a weak association on higher warfarin dose requirements (P=.09).
However, analysing these variant alleles in a regression analysis together with our previously reported data on VKORC1*2, CYP2C9*2 and CYP2C9*3 polymorphisms, gave no significant associations for neither VKORC1*3, VKORC1*4 nor CYP4F2 (1347 C > T).
In conclusion, in patients with myocardial infarction, the individual contribution to warfarin dose requirements from VKORC1*3, VKORC1*4, and CYP4F2 (1347 C > T) polymorphisms was negligible.
Our results indicate that pharmacogenetic testing for VKORC1*2, CYP2C9*2 and CYP2C9*3 is more informative regarding warfarin dose requirements than testing for VKORC1*3, VKORC1*4, and CYP4F2 (1347 C > T) polymorphisms.
American Psychological Association (APA)
Kringen, Marianne K.& Haug, Kari Bente Foss& Grimholt, Runa M.& Stormo, Camilla& Narum, Sigrid& Opdal, Mimi S.…[et al.]. 2010. Genetic Variation of VKORC1 and CYP4F2 Genes Related to Warfarin Maintenance Dose in Patients with Myocardial Infarction. BioMed Research International،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990271
Modern Language Association (MLA)
Kringen, Marianne K.…[et al.]. Genetic Variation of VKORC1 and CYP4F2 Genes Related to Warfarin Maintenance Dose in Patients with Myocardial Infarction. BioMed Research International No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-990271
American Medical Association (AMA)
Kringen, Marianne K.& Haug, Kari Bente Foss& Grimholt, Runa M.& Stormo, Camilla& Narum, Sigrid& Opdal, Mimi S.…[et al.]. Genetic Variation of VKORC1 and CYP4F2 Genes Related to Warfarin Maintenance Dose in Patients with Myocardial Infarction. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990271