Proteomics in Molecular Diagnosis: Typing of Amyloidosis
Joint Authors
Mollee, Peter N.
Hill, Michelle M.
Renaut, Patricia
Loo, Dorothy
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Amyloidosis is a group of disorders caused by deposition of misfolded proteins as aggregates in the extracellular tissues of the body, leading to impairment of organ function.
Correct identification of the causal amyloid protein is absolutely crucial for clinical management in order to avoid misdiagnosis and inappropriate, potentially harmful treatment, to assess prognosis and to offer genetic counselling if relevant.
Current diagnostic methods, including antibody-based amyloid typing, have limited ability to detect the full range of amyloid forming proteins.
Recent investigations into proteomic identification of amyloid protein have shown promise.
This paper will review the current state of the art in proteomic analysis of amyloidosis, discuss the suitability of techniques based on the properties of amyloidosis, and further suggest potential areas of development.
Establishment of mass spectrometry aided amyloid typing procedures in the pathology laboratory will allow accurate amyloidosis diagnosis in a timely manner and greatly facilitate clinical management of the disease.
American Psychological Association (APA)
Loo, Dorothy& Mollee, Peter N.& Renaut, Patricia& Hill, Michelle M.. 2011. Proteomics in Molecular Diagnosis: Typing of Amyloidosis. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990274
Modern Language Association (MLA)
Loo, Dorothy…[et al.]. Proteomics in Molecular Diagnosis: Typing of Amyloidosis. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-990274
American Medical Association (AMA)
Loo, Dorothy& Mollee, Peter N.& Renaut, Patricia& Hill, Michelle M.. Proteomics in Molecular Diagnosis: Typing of Amyloidosis. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990274