Evaluation of Itch by Using NCNgaTnd Mice: A Model of Human Atopic Dermatitis
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Atopic dermatitis (AD) is the extremely complicated syndrome that various abnormalities develop in a heap.
There are various factors in patients for the onset and exacerbation of AD, including genetic cofactors of individuals, environmental factors, the failure of the skin barrier function, unfavorable regulation of the immune system, and the hypersensitivity of sensory nerves.
In recent years, there have been many trials of the drug discovery that targets itch, because itch is one of the most serious clinical symptoms of AD.
The selection of the suitable animal model that represents the condition of patients, as well as innovative analyzing protocols that can precisely evaluate itch, is indispensable for investigation of an effective drug for AD.
In the paper, the unique spontaneous animal model for AD (NC/NgaTnd mice) and the novel quantification system of the laboratory animals that may bring a great progress in the future study of itch are outlined.
American Psychological Association (APA)
Tanaka, Akane& Matsuda, Hiroshi. 2010. Evaluation of Itch by Using NCNgaTnd Mice: A Model of Human Atopic Dermatitis. BioMed Research International،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990286
Modern Language Association (MLA)
Tanaka, Akane& Matsuda, Hiroshi. Evaluation of Itch by Using NCNgaTnd Mice: A Model of Human Atopic Dermatitis. BioMed Research International No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-990286
American Medical Association (AMA)
Tanaka, Akane& Matsuda, Hiroshi. Evaluation of Itch by Using NCNgaTnd Mice: A Model of Human Atopic Dermatitis. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990286