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Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells
Joint Authors
Uusitalo, Hannu
Salminen, Antero
Ryhänen, Tuomas
Hyttinen, Juha M. T.
Kaarniranta, Kai
Viiri, Johanna
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Retinal pigment epithelial (RPE) cells are continually exposed to oxidative stress that contributes to protein misfolding, aggregation and functional abnormalities during aging.
The protein aggregates formed at the cell periphery are delivered along the microtubulus network by dynein-dependent retrograde trafficking to a juxtanuclear location.
We demonstrate that Hsp90 inhibition by geldanamycin can effectively suppress proteasome inhibitor, MG-132-induced protein aggregation in a way that is independent of HDAC inhibition or the tubulin acetylation levels in ARPE-19 cells.
However, the tubulin acetylation and polymerization state affects the localization of the proteasome-inhibitor-induced aggregation.
These findings open new perspectives for understanding the pathogenesis of protein aggregation in retinal cells and can be useful for the development of therapeutic treatments to prevent retinal cell deterioration.
American Psychological Association (APA)
Ryhänen, Tuomas& Viiri, Johanna& Hyttinen, Juha M. T.& Uusitalo, Hannu& Salminen, Antero& Kaarniranta, Kai. 2010. Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990291
Modern Language Association (MLA)
Ryhänen, Tuomas…[et al.]. Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-990291
American Medical Association (AMA)
Ryhänen, Tuomas& Viiri, Johanna& Hyttinen, Juha M. T.& Uusitalo, Hannu& Salminen, Antero& Kaarniranta, Kai. Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990291
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990291