Role of Positive Selection in Functional Divergence of Mammalian Neuronal Apoptosis Inhibitor Proteins during Evolution
Joint Authors
Wang, Shengjun
Fang, Jie
Zhou, Chenglin
Kong, Fanzhi
Yuan, Hongyan
Sun, Caixia
Zheng, Dong
Su, Zhaoliang
Yin, Jingping
Liu, Yanfang
Su, Zhaoliang
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Neuronal apoptosis inhibitor proteins (NAIPs) are members of Nod-like receptor (NLR) protein family.
Recent research demostrated that some NAIP genes were strongly associated with both innate immunity and many inflammatory diseases in humans.
However, no similar phenomena have been reported in other mammals.
Furthermore, some NAIP genes have undergone pseudogenization or have been lost during the evolution of some higher mammals.
We therefore aimed to determine if functional divergence had occurred, and if natural selection had played an important role in the evolution of these genes.
The results showed that NAIP genes have undergone pseudogenization and functional divergence, driven by positive selection.
Positive selection has also influenced NAIP protein structure, resulting in further functional divergence.
American Psychological Association (APA)
Kong, Fanzhi& Su, Zhaoliang& Zhou, Chenglin& Sun, Caixia& Liu, Yanfang& Zheng, Dong…[et al.]. 2011. Role of Positive Selection in Functional Divergence of Mammalian Neuronal Apoptosis Inhibitor Proteins during Evolution. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990297
Modern Language Association (MLA)
Kong, Fanzhi…[et al.]. Role of Positive Selection in Functional Divergence of Mammalian Neuronal Apoptosis Inhibitor Proteins during Evolution. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-990297
American Medical Association (AMA)
Kong, Fanzhi& Su, Zhaoliang& Zhou, Chenglin& Sun, Caixia& Liu, Yanfang& Zheng, Dong…[et al.]. Role of Positive Selection in Functional Divergence of Mammalian Neuronal Apoptosis Inhibitor Proteins during Evolution. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990297
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990297