Characteristics of Highly Polymorphic Segmental Copy-Number Variations Observed in Japanese by BAC-Array-CGH
Joint Authors
Takahashi, Norio
Sasaki, Keiko
Shimoichi, Yuko
Sugita, Keiko
Satoh, Yasunari
Katayama, Hiroaki
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Segmental copy-number variations (CNVs) may contribute to genetic variation in humans.
Reports of the existence and characteristics of CNVs in a large Japanese cohort are quite limited.
We report the data from a large Japanese population.
We conducted population screening for 213 unrelated Japanese individuals using comparative genomic hybridization based on a bacterial artificial chromosome microarray (BAC-aCGH).
We summarize the data by focusing on highly polymorphic CNVs in ≥5.0% of the individual, since they may be informative for demonstrating the relationships between genotypes and their phenotypes.
We found a total of 680 CNVs at 16 different BAC-regions in the genome.
The majority of the polymorphic CNVs presented on BAC-clones that overlapped with regions of segmental duplication, and the majority of the polymorphic CNVs observed in this population had been previously reported in other publications.
Some of the CNVs contained genes which might be related to phenotypic heterogeneity among individuals.
American Psychological Association (APA)
Takahashi, Norio& Satoh, Yasunari& Sasaki, Keiko& Shimoichi, Yuko& Sugita, Keiko& Katayama, Hiroaki. 2010. Characteristics of Highly Polymorphic Segmental Copy-Number Variations Observed in Japanese by BAC-Array-CGH. BioMed Research International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990310
Modern Language Association (MLA)
Takahashi, Norio…[et al.]. Characteristics of Highly Polymorphic Segmental Copy-Number Variations Observed in Japanese by BAC-Array-CGH. BioMed Research International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-990310
American Medical Association (AMA)
Takahashi, Norio& Satoh, Yasunari& Sasaki, Keiko& Shimoichi, Yuko& Sugita, Keiko& Katayama, Hiroaki. Characteristics of Highly Polymorphic Segmental Copy-Number Variations Observed in Japanese by BAC-Array-CGH. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990310