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Epithelial Cell Coculture Models for Studying Infectious Diseases: Benefits and Limitations
Joint Authors
Cripps, Allan W.
Ulett, Glen C.
Schembri, Mark A.
Duell, Benjamin L.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Countless in vitro cell culture models based on the use of epithelial cell types of single lineages have been characterized and have provided insight into the mechanisms of infection for various microbial pathogens.
Diverse culture models based on disease-relevant mucosal epithelial cell types derived from gastrointestinal, genitourinary, and pulmonary organ systems have delineated many key host-pathogen interactions that underlie viral, parasitic, and bacterial disease pathogenesis.
An alternative to single lineage epithelial cell monoculture, which offers more flexibility and can overcome some of the limitations of epithelial cell culture models based on only single cell types, is coculture of epithelial cells with other host cell types.
Various coculture models have been described, which incorporate epithelial cell types in culture combination with a wide range of other cell types including neutrophils, eosinophils, monocytes, and lymphocytes.
This paper will summarize current models of epithelial cell coculture and will discuss the benefits and limitations of epithelial cell coculture for studying host-pathogen dynamics in infectious diseases.
American Psychological Association (APA)
Duell, Benjamin L.& Cripps, Allan W.& Schembri, Mark A.& Ulett, Glen C.. 2011. Epithelial Cell Coculture Models for Studying Infectious Diseases: Benefits and Limitations. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990345
Modern Language Association (MLA)
Duell, Benjamin L.…[et al.]. Epithelial Cell Coculture Models for Studying Infectious Diseases: Benefits and Limitations. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-990345
American Medical Association (AMA)
Duell, Benjamin L.& Cripps, Allan W.& Schembri, Mark A.& Ulett, Glen C.. Epithelial Cell Coculture Models for Studying Infectious Diseases: Benefits and Limitations. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990345