Role of Common-Gamma Chain Cytokines in NK Cell Development and Function: Perspectives for Immunotherapy
Joint Authors
Azzarone, Bruno
Ferrini, Silvano
Meazza, Raffaella
Orengo, Anna Maria
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-13
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
NK cells are components of the innate immunity system and play an important role as a first-line defense mechanism against viral infections and in tumor immune surveillance.
Their development and their functional activities are controlled by several factors among which cytokines sharing the usage of the common cytokine-receptor gamma chain play a pivotal role.
In particular, IL-2, IL-7, IL-15, and IL-21 are the members of this family predominantly involved in NK cell biology.
In this paper, we will address their role in NK cell ontogeny, regulation of functional activities, development of specialized cell subsets, and acquisition of memory-like functions.
Finally, the potential application of these cytokines as recombinant molecules to NK cell-based immunotherapy approaches will be discussed.
American Psychological Association (APA)
Meazza, Raffaella& Azzarone, Bruno& Orengo, Anna Maria& Ferrini, Silvano. 2011. Role of Common-Gamma Chain Cytokines in NK Cell Development and Function: Perspectives for Immunotherapy. BioMed Research International،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-990355
Modern Language Association (MLA)
Meazza, Raffaella…[et al.]. Role of Common-Gamma Chain Cytokines in NK Cell Development and Function: Perspectives for Immunotherapy. BioMed Research International No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-990355
American Medical Association (AMA)
Meazza, Raffaella& Azzarone, Bruno& Orengo, Anna Maria& Ferrini, Silvano. Role of Common-Gamma Chain Cytokines in NK Cell Development and Function: Perspectives for Immunotherapy. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-990355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990355