A Symphony of Regulations Centered on p63 to Control Development of Ectoderm-Derived Structures
Joint Authors
Costanzo, Antonio
Merlo, Giorgio R.
Guerrini, Luisa
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The p53-related transcription factor p63 is critically important for basic cellular functions during development of the ectoderm and derived structure and tissues, including skin, limb, palate, and hair.
On the one side, p63 is required to sustain the proliferation of keratinocyte progenitors, while on the other side it is required for cell stratification, commitment to differentiate, cell adhesion, and epithelial-mesenchymal signaling.
Molecules that are components or regulators of the p63 pathway(s) are rapidly being identified, and it comes with no surprise that alterations in the p63 pathway lead to congenital conditions in which the skin and other ectoderm-derived structures are affected.
In this paper, we summarize the current knowledge of the molecular and cellular regulations centered on p63, derived from the comprehension of p63-linked human diseases and the corresponding animal models, as well as from cellular models and high-throughput molecular approaches.
We point out common themes and features, that allow to speculate on the possible role of p63 downstream events and their potential exploitation in future attempts to correct the congenital defect in preclinical studies.
American Psychological Association (APA)
Guerrini, Luisa& Costanzo, Antonio& Merlo, Giorgio R.. 2011. A Symphony of Regulations Centered on p63 to Control Development of Ectoderm-Derived Structures. BioMed Research International،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-990357
Modern Language Association (MLA)
Guerrini, Luisa…[et al.]. A Symphony of Regulations Centered on p63 to Control Development of Ectoderm-Derived Structures. BioMed Research International No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-990357
American Medical Association (AMA)
Guerrini, Luisa& Costanzo, Antonio& Merlo, Giorgio R.. A Symphony of Regulations Centered on p63 to Control Development of Ectoderm-Derived Structures. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-990357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990357