The Role of HDAC6 in Cancer
Joint Authors
Aldana-Masangkay, Grace I.
Sakamoto, Kathleen M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Histone deacetylase 6 (HDAC6), a member of the HDAC family whose major substrate is α-tubulin, has become a target for drug development to treat cancer due to its major contribution in oncogenic cell transformation.
Overexpression of HDAC6 correlates with tumorigenesis and improved survival; therefore, HDAC6 may be used as a marker for prognosis.
Previous work demonstrated that in multiple myeloma cells, inhibition of HDAC6 results in apoptosis.
Furthermore, HDAC6 is required for the activation of heat-shock factor 1 (HSF1), an activator of heat-shock protein encoding genes (HSPs) and CYLD, a cylindromatosis tumor suppressor gene.
HDAC6 contributes to cancer metastasis since its upregulation increases cell motility in breast cancer MCF-7 cells and its interaction with cortactin regulates motility.
HDAC6 also affects transcription and translation by regulating the heat-shock protein 90 (Hsp90) and stress granules (SGs), respectively.
This review will discuss the role of HDAC6 in the pathogenesis and treatment of cancer.
American Psychological Association (APA)
Aldana-Masangkay, Grace I.& Sakamoto, Kathleen M.. 2010. The Role of HDAC6 in Cancer. BioMed Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990364
Modern Language Association (MLA)
Aldana-Masangkay, Grace I.& Sakamoto, Kathleen M.. The Role of HDAC6 in Cancer. BioMed Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-990364
American Medical Association (AMA)
Aldana-Masangkay, Grace I.& Sakamoto, Kathleen M.. The Role of HDAC6 in Cancer. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990364
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990364