Functions of MDMX in the Modulation of the p53-Response
Joint Authors
Lenos, Kristiaan
Jochemsen, Aart G.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The MDM family proteins MDM2 and MDMX are two critical regulators of the p53 tumor suppressor protein.
Expression of both proteins is necessary for allowing the embryonal development by keeping the activity of p53 in check.
Upon stresses that need to activate p53 to perform its function as guardian of the genome, p53 has to be liberated from these two inhibitors.
In this review, we will discuss the various mechanisms by which MDMX protein levels are downregulated upon various types of stress, including posttranslational modifications of the MDMX protein and the regulation of mdmx mRNA expression, including alternative splicing.
In addition, the putative function(s) of the described MDMX splice variants, particularly in tumor development, will be discussed.
Lastly, in contrast to common belief, we have recently shown the existence of a p53-MDMX feedback loop, which is important for dampening the p53-response at later phases after genotoxic stress.
American Psychological Association (APA)
Lenos, Kristiaan& Jochemsen, Aart G.. 2011. Functions of MDMX in the Modulation of the p53-Response. BioMed Research International،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-990365
Modern Language Association (MLA)
Lenos, Kristiaan& Jochemsen, Aart G.. Functions of MDMX in the Modulation of the p53-Response. BioMed Research International No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-990365
American Medical Association (AMA)
Lenos, Kristiaan& Jochemsen, Aart G.. Functions of MDMX in the Modulation of the p53-Response. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-990365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990365