Elongator: An Ancestral Complex Driving Transcription and Migration through Protein Acetylation
Joint Authors
Buschbeck, Marcus
Creppe, Catherine
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Elongator is an evolutionary highly conserved complex.
At least two of its cellular functions rely on the intrinsic lysine acetyl-transferase activity of the Elongator complex.
Its two known substrates—Histone H3 and α-Tubulin—reflect the different roles of Elongator in the cytosol and the nucleus.
A picture seems to emerge in which nuclear Elongator could regulate the transcriptional elongation of a subset of stress-inducible genes through acetylation of Histone H3 in the promoter-distal gene body.
In the cytosol, Elongator-mediated acetylation of α-Tubulin contributes to intracellular trafficking and cell migration.
Defects in both functions of Elongator have been implicated in neurodegenerative disorders.
American Psychological Association (APA)
Creppe, Catherine& Buschbeck, Marcus. 2010. Elongator: An Ancestral Complex Driving Transcription and Migration through Protein Acetylation. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990386
Modern Language Association (MLA)
Creppe, Catherine& Buschbeck, Marcus. Elongator: An Ancestral Complex Driving Transcription and Migration through Protein Acetylation. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-990386
American Medical Association (AMA)
Creppe, Catherine& Buschbeck, Marcus. Elongator: An Ancestral Complex Driving Transcription and Migration through Protein Acetylation. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990386