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Th Subset Balance in Lupus Nephritis
Joint Authors
Akahoshi, Mitsuteru
Nakashima, Hitoshi
Miyake, Katsuhisa
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Lupus nephritis, which has various histological patterns and variable clinical outcomes, is one of the most important complications of systemic lupus nephritis (SLE).
This pathogenetic mechanism in each histologically different type of lupus nephritis (LN) remains unclear.
Although SLE is suggested to be a Th2-driven disease, elevation of both Th1 and Th2 cytokines occurs in both humans and mice, suggesting that SLE is a complex disease driven by different lymphocyte subsets with high heterogeneity of clinical manifestations and organ involvement.
Recent findings in LN elucidate an essential role for the Th1, IL-17 producing T cells and Th17 cells in the development of diffuse proliferative lupus nephritis (DPLN), and Th2 cytokine in that of membranous lupus nephritis (MLN).
These data support the hypothesis that individual Th1/Th2 balance is one of the critical determinants for histopathology of LN.
American Psychological Association (APA)
Miyake, Katsuhisa& Akahoshi, Mitsuteru& Nakashima, Hitoshi. 2011. Th Subset Balance in Lupus Nephritis. BioMed Research International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990442
Modern Language Association (MLA)
Miyake, Katsuhisa…[et al.]. Th Subset Balance in Lupus Nephritis. BioMed Research International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-990442
American Medical Association (AMA)
Miyake, Katsuhisa& Akahoshi, Mitsuteru& Nakashima, Hitoshi. Th Subset Balance in Lupus Nephritis. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990442