Early-Life Origins of Type 2 Diabetes: Fetal Programming of the Beta-Cell Mass

Joint Authors

Portha, Bernard
Movassat, Jamileh
Chavey, Audrey

Source

Journal of Diabetes Research

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-10-24

Country of Publication

Egypt

No. of Pages

16

Main Subjects

Diseases
Medicine

Abstract EN

A substantial body of evidence suggests that an abnormal intrauterine milieu elicited by maternal metabolic disturbances as diverse as undernutrition, placental insufficiency, diabetes or obesity, may program susceptibility in the fetus to later develop chronic degenerative diseases, such as obesity, hypertension, cardiovascular diseases and diabetes.

This paper examines the developmental programming of glucose intolerance/diabetes by disturbed intrauterine metabolic condition experimentally obtained in various rodent models of maternal protein restriction, caloric restriction, overnutrition or diabetes, with a focus on the alteration of the developing beta-cell mass.

In most of the cases, whatever the type of initial maternal metabolic stress, the beta-cell adaptive growth which normally occurs during gestation, does not take place in the pregnant offspring and this results in the development of gestational diabetes.

Therefore gestational diabetes turns to be the ultimate insult targeting the offspring beta-cell mass and propagates diabetes risk to the next generation again.

The aetiology and the transmission of spontaneous diabetes as encountered in the GK/Par rat model of type 2 diabetes, are discussed in such a perspective.

This review also discusses the non-genomic mechanisms involved in the installation of the programmed effect as well as in its intergenerational transmission.

American Psychological Association (APA)

Portha, Bernard& Chavey, Audrey& Movassat, Jamileh. 2011. Early-Life Origins of Type 2 Diabetes: Fetal Programming of the Beta-Cell Mass. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-990615

Modern Language Association (MLA)

Portha, Bernard…[et al.]. Early-Life Origins of Type 2 Diabetes: Fetal Programming of the Beta-Cell Mass. Journal of Diabetes Research No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-990615

American Medical Association (AMA)

Portha, Bernard& Chavey, Audrey& Movassat, Jamileh. Early-Life Origins of Type 2 Diabetes: Fetal Programming of the Beta-Cell Mass. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-990615

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-990615