Insulin Receptor Substrate 2 Expression and Involvement in Neuronal Insulin Resistance in Diabetic Neuropathy

Joint Authors

Grote, C. W.
Geiger, P. C.
Morris, J. K.
Wright, Douglas E.
Ryals, J. M.

Source

Journal of Diabetes Research

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-06-15

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases
Medicine

Abstract EN

Insulin signaling depends on tyrosine phosphorylation of insulin receptor substrates (IRSs) to mediate downstream effects; however, elevated serine phosphorylation of IRS impairs insulin signaling.

Here, we investigated IRS protein expression patterns in dorsal root ganglia (DRG) of mice and whether their signaling was affected by diabetes.

Both IRS1 and IRS2 are expressed in DRG; however, IRS2 appears to be the prevalent isoform and is expressed by many DRG neuronal subtypes.

Phosphorylation of Ser(731)IRS2 was significantly elevated in DRG neurons from type 1 and type 2 diabetic mice.

Additionally, Akt activation and neurite outgrowth in response to insulin were significantly decreased in DRG cultures from diabetic ob/ob mice.

These results suggest that DRG neurons express IRS proteins that are altered by diabetes similar to other peripheral tissues, and insulin signaling downstream of the insulin receptor may be impaired in sensory neurons and contribute to the pathogenesis of diabetic neuropathy.

American Psychological Association (APA)

Grote, C. W.& Morris, J. K.& Ryals, J. M.& Geiger, P. C.& Wright, Douglas E.. 2011. Insulin Receptor Substrate 2 Expression and Involvement in Neuronal Insulin Resistance in Diabetic Neuropathy. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990621

Modern Language Association (MLA)

Grote, C. W.…[et al.]. Insulin Receptor Substrate 2 Expression and Involvement in Neuronal Insulin Resistance in Diabetic Neuropathy. Journal of Diabetes Research No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-990621

American Medical Association (AMA)

Grote, C. W.& Morris, J. K.& Ryals, J. M.& Geiger, P. C.& Wright, Douglas E.. Insulin Receptor Substrate 2 Expression and Involvement in Neuronal Insulin Resistance in Diabetic Neuropathy. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990621

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-990621