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Glucagon-Like Peptide-1 Receptor Agonists and Cardiovascular Events: A Meta-Analysis of Randomized Clinical Trials
Joint Authors
Monami, Matteo
Niccolò, Marchionni
Colombi, Claudia
Desideri, Carla Maria
Lamanna, Caterina
Cremasco, Francesco
Iacomelli, Iacopo
Mannucci, Edoardo
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Data from randomized clinical trials with metabolic outcomes can be used to address concerns about potential issues of cardiovascular safety for newer drugs for type 2 diabetes.
This meta-analysis was designed to assess cardiovascular safety of GLP-1 receptor agonists.
Design and Methods.
MEDLINE, Embase, and Cochrane databases were searched for randomized trials of GLP-1 receptor agonists (versus placebo or other comparators) with a duration ≥12 weeks, performed in type 2 diabetic patients.
Mantel-Haenszel odds ratio with 95% confidence interval (MH-OR) was calculated for major cardiovascular events (MACE), on an intention-to-treat basis, excluding trials with zero events.
Results.
Out of 36 trials, 20 reported at least one MACE.
The MH-OR for all GLP-1 receptor agonists was 0.74 (0.50–1.08), P=.12 (0.85 (0.50–1.45), P=.55, and 0.69 (0.40–1.22), P=.20, for exenatide and liraglutide, resp.).
Corresponding figures for placebo-controlled and active comparator studies were 0.46 (0.25–0.83), P=.009, and 1.05 (0.63–1.76), P=.84, respectively.
Conclusions.
To date, results of randomized trials do not suggest any detrimental effect of GLP-1 receptor agonists on cardiovascular events.
Specifically designed longer-term trials are needed to verify the possibility of a beneficial effect.
American Psychological Association (APA)
Monami, Matteo& Cremasco, Francesco& Lamanna, Caterina& Colombi, Claudia& Desideri, Carla Maria& Iacomelli, Iacopo…[et al.]. 2011. Glucagon-Like Peptide-1 Receptor Agonists and Cardiovascular Events: A Meta-Analysis of Randomized Clinical Trials. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990622
Modern Language Association (MLA)
Monami, Matteo…[et al.]. Glucagon-Like Peptide-1 Receptor Agonists and Cardiovascular Events: A Meta-Analysis of Randomized Clinical Trials. Journal of Diabetes Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-990622
American Medical Association (AMA)
Monami, Matteo& Cremasco, Francesco& Lamanna, Caterina& Colombi, Claudia& Desideri, Carla Maria& Iacomelli, Iacopo…[et al.]. Glucagon-Like Peptide-1 Receptor Agonists and Cardiovascular Events: A Meta-Analysis of Randomized Clinical Trials. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990622