Dysregulation of the Intrarenal Vitamin D Endocytic Pathway in a Nephropathy-Prone Mouse Model of Type 1 Diabetes
Joint Authors
Fowlkes, John L.
Thrailkill, Kathryn M.
Bunn, R. Clay
Cockrell, Gael E.
Wahl, Elizabeth C.
Clark, Lindsey M.
Lumpkin, Charles K.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Microalbuminuria in humans with Type 1 diabetes (T1D) is associated with increased urinary excretion of megalin, as well as many megalin ligands, including vitamin-D-binding protein (VDBP).
We examined the DBA/2J diabetic mouse, nephropathy prone model, to determine if megalin and VDBP excretion coincide with the development of diabetic nephropathy.
Megalin, VDBP, and 25-hydroxy-vitamin D (25-OHD) were measured in urine, and genes involved in vitamin D metabolism were assessed in renal tissues from diabetic and control mice at 10, 15, and 18 weeks following the onset of diabetes.
Megalin, VDBP, and 25-OHD were increased in the urine of diabetic mice.
1-α hydroxylase (CYP27B1) mRNA in the kidney was persistently increased in diabetic mice, as were several vitamin D-target genes.
These studies show that intrarenal vitamin D handling is altered in the diabetic kidney, and they suggest that in T1D, urinary losses of VDBP may portend risk for intrarenal and extrarenal vitamin D deficiencies.
American Psychological Association (APA)
Fowlkes, John L.& Bunn, R. Clay& Cockrell, Gael E.& Clark, Lindsey M.& Wahl, Elizabeth C.& Lumpkin, Charles K.…[et al.]. 2011. Dysregulation of the Intrarenal Vitamin D Endocytic Pathway in a Nephropathy-Prone Mouse Model of Type 1 Diabetes. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990624
Modern Language Association (MLA)
Fowlkes, John L.…[et al.]. Dysregulation of the Intrarenal Vitamin D Endocytic Pathway in a Nephropathy-Prone Mouse Model of Type 1 Diabetes. Journal of Diabetes Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-990624
American Medical Association (AMA)
Fowlkes, John L.& Bunn, R. Clay& Cockrell, Gael E.& Clark, Lindsey M.& Wahl, Elizabeth C.& Lumpkin, Charles K.…[et al.]. Dysregulation of the Intrarenal Vitamin D Endocytic Pathway in a Nephropathy-Prone Mouse Model of Type 1 Diabetes. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990624