Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities
Joint Authors
Baldasseroni, Samuele
Mello, Anna Maria
Monami, Matteo
Niccolò, Marchionni
Boncinelli, Marta
Tarantini, Francesca
Lonetto, Giuseppe
Ballini, Elena
Mossello, Enrico
Mannucci, Edoardo
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Metabolic and neurodegenerative disorders have a growing prevalence in Western countries.
Available epidemiologic and neurobiological evidences support the existence of a pathophysiological link between these conditions.
Glucagon-like peptide 1 (GLP-1), whose activity is reduced in insulin resistance, has been implicated in central nervous system function, including cognition, synaptic plasticity, and neurogenesis.
We review the experimental researches suggesting that GLP-1 dysfunction might be a mediating factor between Type 2 diabetes mellitus (T2DM) and neurodegeneration.
Drug treatments enhancing GLP-1 activity hold out hope for treatment and prevention of Alzheimer's disease (AD) and cognitive decline.
American Psychological Association (APA)
Mossello, Enrico& Ballini, Elena& Boncinelli, Marta& Monami, Matteo& Lonetto, Giuseppe& Mello, Anna Maria…[et al.]. 2011. Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990627
Modern Language Association (MLA)
Mossello, Enrico…[et al.]. Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities. Journal of Diabetes Research No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-990627
American Medical Association (AMA)
Mossello, Enrico& Ballini, Elena& Boncinelli, Marta& Monami, Matteo& Lonetto, Giuseppe& Mello, Anna Maria…[et al.]. Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990627
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990627