Immortalized Adult Rodent Schwann Cells as In Vitro Models to Study Diabetic Neuropathy
Joint Authors
Sango, Kazunori
Takaku, Shizuka
Watabe, Kazuhiko
Kawakami, Emiko
Yanagisawa, Hiroko
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We have established spontaneously immortalized Schwann cell lines from normal adult mice and rats and murine disease models.
One of the normal mouse cell lines, IMS32, possesses some biological properties of mature Schwann cells and high proliferative activities.
The IMS32 cells under hyperglycemic and/or hyperlipidemic conditions have been utilized to investigate the pathogenesis of diabetic neuropathy, especially the polyol pathway hyperactivity, glycation, increased oxidative stress, and reduced synthesis of neurotrophic factors.
In addition to the mouse cell lines, our current study focuses on the characterization of a normal rat cell line, IFRS1, under normal and high glucose conditions.
These Schwann cell lines can be valuable tools for exploring the detailed mechanisms leading to diabetic neuropathy and novel therapeutic approaches against that condition.
American Psychological Association (APA)
Sango, Kazunori& Yanagisawa, Hiroko& Takaku, Shizuka& Kawakami, Emiko& Watabe, Kazuhiko. 2011. Immortalized Adult Rodent Schwann Cells as In Vitro Models to Study Diabetic Neuropathy. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990631
Modern Language Association (MLA)
Sango, Kazunori…[et al.]. Immortalized Adult Rodent Schwann Cells as In Vitro Models to Study Diabetic Neuropathy. Journal of Diabetes Research No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-990631
American Medical Association (AMA)
Sango, Kazunori& Yanagisawa, Hiroko& Takaku, Shizuka& Kawakami, Emiko& Watabe, Kazuhiko. Immortalized Adult Rodent Schwann Cells as In Vitro Models to Study Diabetic Neuropathy. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990631