Activation of the GLP-1 Receptor Signalling Pathway: A Relevant Strategy to Repair a Deficient Beta-Cell Mass
Joint Authors
Portha, Bernard
Movassat, Jamileh
Tourrel-Cuzin, Cécile
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Recent preclinical studies in rodent models of diabetes suggest that exogenous GLP-1R agonists and DPP-4 inhibitors have the ability to increase islet mass and preserve beta-cell function, by immediate reactivation of beta-cell glucose competence, as well as enhanced beta-cell proliferation and neogenesis and promotion of beta-cell survival.
These effects have tremendous implication in the treatment of T2D because they directly address one of the basic defects in T2D, that is, beta-cell failure.
In human diabetes, however, evidence that the GLP-1-based drugs alter the course of beta-cell function remains to be found.
Several questions surrounding the risks and benefits of GLP-1-based therapy for the diabetic beta-cell mass are discussed in this review and require further investigation.
American Psychological Association (APA)
Portha, Bernard& Tourrel-Cuzin, Cécile& Movassat, Jamileh. 2011. Activation of the GLP-1 Receptor Signalling Pathway: A Relevant Strategy to Repair a Deficient Beta-Cell Mass. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990632
Modern Language Association (MLA)
Portha, Bernard…[et al.]. Activation of the GLP-1 Receptor Signalling Pathway: A Relevant Strategy to Repair a Deficient Beta-Cell Mass. Journal of Diabetes Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-990632
American Medical Association (AMA)
Portha, Bernard& Tourrel-Cuzin, Cécile& Movassat, Jamileh. Activation of the GLP-1 Receptor Signalling Pathway: A Relevant Strategy to Repair a Deficient Beta-Cell Mass. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990632
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990632