Extrinsic Factors Involved in the Differentiation of Stem Cells into Insulin-Producing Cells: An Overview
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Diabetes mellitus is a chronic disease with many debilitating complications.
Treatment of diabetes mellitus mainly revolves around conventional oral hypoglycaemic agents and insulin replacement therapy.
Recently, scientists have turned their attention to the generation of insulin-producing cells (IPCs) from stem cells of various sources.
To date, many types of stem cells of human and animal origins have been successfully turned into IPCs in vitro and have been shown to exert glucose-lowering effect in vivo.
However, scientists are still faced with the challenge of producing a sufficient number of IPCs that can in turn produce sufficient insulin for clinical use.
A careful choice of stem cells, methods, and extrinsic factors for induction may all be contributing factors to successful production of functional beta-islet like IPCs.
It is also important that the mechanism of differentiation and mechanism by which IPCs correct hyperglycaemia are carefully studied before they are used in human subjects.
American Psychological Association (APA)
Wong, Rebecca S. Y.. 2011. Extrinsic Factors Involved in the Differentiation of Stem Cells into Insulin-Producing Cells: An Overview. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-990633
Modern Language Association (MLA)
Wong, Rebecca S. Y.. Extrinsic Factors Involved in the Differentiation of Stem Cells into Insulin-Producing Cells: An Overview. Journal of Diabetes Research No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-990633
American Medical Association (AMA)
Wong, Rebecca S. Y.. Extrinsic Factors Involved in the Differentiation of Stem Cells into Insulin-Producing Cells: An Overview. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-990633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990633