Subthreshold α2-Adrenergic Activation Counteracts Glucagon-Like Peptide-1 Potentiation of Glucose-Stimulated Insulin Secretion
Joint Authors
Cui, Xiuli
Yang, Shao-Nian
Yang, Guang
Pan, Minglin
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The pancreatic β cell harbors α2-adrenergic and glucagon-like peptide-1 (GLP-1) receptors on its plasma membrane to sense the corresponding ligands adrenaline/noradrenaline and GLP-1 to govern glucose-stimulated insulin secretion.
However, it is not known whether these two signaling systems interact to gain the adequate and timely control of insulin release in response to glucose.
The present work shows that the α2-adrenergic agonist clonidine concentration-dependently depresses glucose-stimulated insulin secretion from INS-1 cells.
On the contrary, GLP-1 concentration-dependently potentiates insulin secretory response to glucose.
Importantly, the present work reveals that subthreshold α2-adrenergic activation with clonidine counteracts GLP-1 potentiation of glucose-induced insulin secretion.
This counteractory process relies on pertussis toxin- (PTX-) sensitive Gi proteins since it no longer occurs following PTX-mediated inactivation of Gi proteins.
The counteraction of GLP-1 potentiation of glucose-stimulated insulin secretion by subthreshold α2-adrenergic activation is likely to serve as a molecular mechanism for the delicate regulation of insulin release.
American Psychological Association (APA)
Pan, Minglin& Yang, Guang& Cui, Xiuli& Yang, Shao-Nian. 2010. Subthreshold α2-Adrenergic Activation Counteracts Glucagon-Like Peptide-1 Potentiation of Glucose-Stimulated Insulin Secretion. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990662
Modern Language Association (MLA)
Pan, Minglin…[et al.]. Subthreshold α2-Adrenergic Activation Counteracts Glucagon-Like Peptide-1 Potentiation of Glucose-Stimulated Insulin Secretion. Journal of Diabetes Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-990662
American Medical Association (AMA)
Pan, Minglin& Yang, Guang& Cui, Xiuli& Yang, Shao-Nian. Subthreshold α2-Adrenergic Activation Counteracts Glucagon-Like Peptide-1 Potentiation of Glucose-Stimulated Insulin Secretion. Journal of Diabetes Research. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990662