TRAIL and DcR1 Expressions Are Differentially Regulated in the Pancreatic Islets of STZ- versus CY-Applied NOD Mice
Joint Authors
Balci, Mustafa Kemal
Omer, Abdulkadir
Aydin, Cigdem
Kahraman, Sevim
Dirice, Ercument
Elpek, Gulsum Ozlem
Sanlioglu, Ahter Dilsad
Sanlioglu, Salih
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
TNF-related apoptosis-inducing ligand (TRAIL) is an important component of the immune system.
Although it is well acknowledged that it also has an important role in Type 1 Diabetes (T1D) development, this presumed role has not yet been clearly revealed.
Streptozotocin (STZ) and Cyclophosphamide (CY) are frequently used agents for establishment or acceleration of T1D disease in experimental models, including the non-obese diabetic (NOD) mice.
Although such disease models are very suitable for diabetes research, different expression patterns for various T1D-related molecules may be expected, depending on the action mechanism of the applied agent.
We accelerated diabetes in female NOD mice using STZ or CY and analyzed the expression profiles of TRAIL ligand and receptors throughout disease development.
TRAIL ligand expression followed a completely different pattern in STZ- versus CY-accelerated disease, displaying a prominent increase in the former, while appearing at reduced levels in the latter.
Decoy receptor 1 (DcR1) expression also increased significantly in the pancreatic islets in STZ-induced disease.
Specific increases observed in TRAIL ligand and DcR1 expressions may be part of a defensive strategy of the beta islets against the infiltrating leukocytes, while the immune-suppressive agent CY may partly hold down this defense, contributing further to diabetes development.
American Psychological Association (APA)
Dirice, Ercument& Kahraman, Sevim& Elpek, Gulsum Ozlem& Aydin, Cigdem& Balci, Mustafa Kemal& Omer, Abdulkadir…[et al.]. 2011. TRAIL and DcR1 Expressions Are Differentially Regulated in the Pancreatic Islets of STZ- versus CY-Applied NOD Mice. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990669
Modern Language Association (MLA)
Dirice, Ercument…[et al.]. TRAIL and DcR1 Expressions Are Differentially Regulated in the Pancreatic Islets of STZ- versus CY-Applied NOD Mice. Journal of Diabetes Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-990669
American Medical Association (AMA)
Dirice, Ercument& Kahraman, Sevim& Elpek, Gulsum Ozlem& Aydin, Cigdem& Balci, Mustafa Kemal& Omer, Abdulkadir…[et al.]. TRAIL and DcR1 Expressions Are Differentially Regulated in the Pancreatic Islets of STZ- versus CY-Applied NOD Mice. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990669