Phenotypic Changes in Diabetic Neuropathy Induced by a High-Fat Diet in Diabetic C57Bl6 Mice
Joint Authors
Guilford, B. L.
Wright, Douglas E.
Ryals, J. M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Emerging evidence suggests that dyslipidemia is an independent risk factor for diabetic neuropathy (DN) (reviewed by Vincent et al.
2009).
To experimentally determine how dyslipidemia alters DN, we quantified neuropathic symptoms in diabetic mice fed a high-fat diet.
Streptozotocin-induced diabetic C57BL/6 mice fed a high-fat diet developed dyslipidemia and a painful neuropathy (mechanical allodynia) instead of the insensate neuropathy (mechanical insensitivity) that normally develops in this strain.
Nondiabetic mice fed a high-fat diet also developed dyslipidemia and mechanical allodynia.
Thermal sensitivity was significantly reduced in diabetic compared to nondiabetic mice, but was not worsened by the high-fat diet.
Moreover, diabetic mice fed a high-fat diet had significantly slower sensory and motor nerve conduction velocities compared to nondiabetic mice.
Overall, dyslipidemia resulting from a high-fat diet may modify DN phenotypes and/or increase risk for developing DN.
These results provide new insight as to how dyslipidemia may alter the development and phenotype of diabetic neuropathy.
American Psychological Association (APA)
Guilford, B. L.& Ryals, J. M.& Wright, Douglas E.. 2011. Phenotypic Changes in Diabetic Neuropathy Induced by a High-Fat Diet in Diabetic C57Bl6 Mice. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-990687
Modern Language Association (MLA)
Guilford, B. L.…[et al.]. Phenotypic Changes in Diabetic Neuropathy Induced by a High-Fat Diet in Diabetic C57Bl6 Mice. Journal of Diabetes Research No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-990687
American Medical Association (AMA)
Guilford, B. L.& Ryals, J. M.& Wright, Douglas E.. Phenotypic Changes in Diabetic Neuropathy Induced by a High-Fat Diet in Diabetic C57Bl6 Mice. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-990687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990687