Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins
Joint Authors
Tan, Joanne T. M.
Davies, Michael J.
Moheimani, Fatemeh
Heather, Alison K.
Brown, Bronwyn E.
van Reyk, David M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
During atherosclerosis monocyte-derived macrophages accumulate cholesteryl esters from low-density lipoproteins (LDLs) via lectin-like oxidised LDL receptor-1 (LOX-1) and class AI and AII (SR-AI, SR-AII) and class B (SR-BI, CD36) scavenger receptors.
Here we examined the hypothesis that hyperglycaemia may modulate receptor expression and hence lipid accumulation in macrophages.
Human monocytes were matured into macrophages in 30 versus 5 mM glucose and receptor expression and lipid accumulation quantified.
High glucose elevated LOX1 mRNA, but decreased SR-AI, SR-BI, LDLR, and CD36 mRNA.
SR-BI and CD36 protein levels were decreased.
Normo- and hyperglycaemic cells accumulated cholesteryl esters from modified LDL to a greater extent than control LDL, but total and individual cholesteryl ester accumulation was not affected by glucose levels.
It is concluded that, whilst macrophage scavenger receptor mRNA and protein levels can be modulated by high glucose, these are not key factors in lipid accumulation by human macrophages under the conditions examined.
American Psychological Association (APA)
Moheimani, Fatemeh& Tan, Joanne T. M.& Brown, Bronwyn E.& Heather, Alison K.& van Reyk, David M.& Davies, Michael J.. 2011. Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990688
Modern Language Association (MLA)
Moheimani, Fatemeh…[et al.]. Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins. Journal of Diabetes Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-990688
American Medical Association (AMA)
Moheimani, Fatemeh& Tan, Joanne T. M.& Brown, Bronwyn E.& Heather, Alison K.& van Reyk, David M.& Davies, Michael J.. Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990688