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TGR5: A Novel Target for Weight Maintenance and Glucose Metabolism
Joint Authors
Lou, Guiyu
Chen, Xiaosong
Meng, Zhipeng
Huang, Wendong
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
TGR5, an emerging G protein-coupled receptor, was identified as a membrane receptor for bile acids.
The expression of TGR5 and its function are distinct from the previously identified nuclear bile acid receptor, farnesoid X receptor (FXR).
These two bile acid receptors complement with each other for maintaining bile acid homeostasis and mediating bile acid signaling.
Both receptors are also shown to play roles in regulating inflammation and glucose metabolism.
An interesting finding for TGR5 is its role in energy metabolism.
The discovery of TGR5 expression in brown adipocyte tissues (BATs) and the recent demonstration of BAT in adult human body suggest a potential approach to combat obesity by targeting TGR5 to increase thermogenesis.
We summarize here the latest finding of TGR5 research, especially its role in energy metabolism and glucose homeostasis.
American Psychological Association (APA)
Chen, Xiaosong& Lou, Guiyu& Meng, Zhipeng& Huang, Wendong. 2011. TGR5: A Novel Target for Weight Maintenance and Glucose Metabolism. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990689
Modern Language Association (MLA)
Chen, Xiaosong…[et al.]. TGR5: A Novel Target for Weight Maintenance and Glucose Metabolism. Journal of Diabetes Research No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-990689
American Medical Association (AMA)
Chen, Xiaosong& Lou, Guiyu& Meng, Zhipeng& Huang, Wendong. TGR5: A Novel Target for Weight Maintenance and Glucose Metabolism. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990689