From Theory to Clinical Practice in the Use of GLP-1 Receptor Agonists and DPP-4 Inhibitors Therapy
Joint Authors
Pala, Laura
Rotella, Carlo Maria
Dicembrini, Ilaria
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Promoting long-term adherence to lifestyle modification and choice of antidiabetic agent with low hypoglycemia risk profile and positive weight profile could be the most effective strategy in achieving sustained glycemic control and in reducing comorbidities.
From this perspective, vast interest has been generated by glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 inhibitors (DPP-4i).
In this review our ten-year clinical and laboratory experience by in vitro and in vivo studies is reported.
Herein, we reviewed available data on the efficacy and safety profile of GLP-1 receptor agonists and DPP-4i.
The introduction of incretin hormone-based therapies represents a novel therapeutic strategy, because these drugs not only improve glycemia with minimal risk of hypoglycemia but also have other extraglycemic beneficial effects.
In clinical studies, both GLP-1 receptor agonists and DPP-4i, improve β cell function indexes.
All these agents showed trophic effects on beta-cell mass in animal studies.
The use of these drugs is associated with positive or neucral effect on body weight and improvements in blood pressure, diabetic dyslipidemia, hepatic steazosis markets, and myocardial function.
These effects have the potential to reduce the burden of cardiovascular disease, which is a major cause of mortality in patients with diabetes.
American Psychological Association (APA)
Dicembrini, Ilaria& Pala, Laura& Rotella, Carlo Maria. 2011. From Theory to Clinical Practice in the Use of GLP-1 Receptor Agonists and DPP-4 Inhibitors Therapy. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990690
Modern Language Association (MLA)
Dicembrini, Ilaria…[et al.]. From Theory to Clinical Practice in the Use of GLP-1 Receptor Agonists and DPP-4 Inhibitors Therapy. Journal of Diabetes Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-990690
American Medical Association (AMA)
Dicembrini, Ilaria& Pala, Laura& Rotella, Carlo Maria. From Theory to Clinical Practice in the Use of GLP-1 Receptor Agonists and DPP-4 Inhibitors Therapy. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990690