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Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fafa) Rats: A Model of Type 2 Diabetes
Joint Authors
Kanasaki, Keizo
Takeda, Ai
Kitada, Munehiro
Nagai, Takako
Ito, Hiroki
Koya, Daisuke
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aim.
Despite the beneficial effects of dietary restriction (DR) on lifespan, age-related diseases, including diabetes and cardiovascular diseases, its effects on type 2 diabetic nephropathy remain unknown.
This study examined the renoprotective effects of DR in Wistar fatty (fa/fa) rats (WFRs).
Methods.
WFRs were treated with DR (40% restriction) for 24 weeks.
Urinary albumin excretion, creatinine clearance, renal histologies, acetylated-NF-κB (p65), Sirt1 protein expression, and p62/Sqstm 1 accumulation in the renal cortex, as well as electron microscopic observation of mitochondrial morphology and autophagosomes in proximal tubular cells were estimated.
Results.
DR ameliorated renal abnormalities including inflammation in WFRs.
The decrease in Sirt1 levels, increase in acetylated-NF-κB, and impaired autophagy in WFRs were improved by DR.
Conclusions.
DR exerted anti-inflammatory effects and improved the dysregulation of autophagy through the restoration of Sirt1 in the kidneys of WFRs, which resulted in the amelioration of renal injuries in type 2 diabetes.
American Psychological Association (APA)
Kitada, Munehiro& Takeda, Ai& Nagai, Takako& Ito, Hiroki& Kanasaki, Keizo& Koya, Daisuke. 2011. Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fafa) Rats: A Model of Type 2 Diabetes. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990693
Modern Language Association (MLA)
Kitada, Munehiro…[et al.]. Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fafa) Rats: A Model of Type 2 Diabetes. Journal of Diabetes Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-990693
American Medical Association (AMA)
Kitada, Munehiro& Takeda, Ai& Nagai, Takako& Ito, Hiroki& Kanasaki, Keizo& Koya, Daisuke. Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fafa) Rats: A Model of Type 2 Diabetes. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990693