Evaluation of Wedged Arterial Injection as a New Technique for Delivery of Experimental Therapeutic Sustances into the Porcine Pancreas
Joint Authors
Sun, Fei
Vázquez, Jose M.
López-Albors, Octavio
Sánchez-Margallo, Francisco M.
Hernández, Wendy
Gil, Francisco
Usón, Jesús
Latorre, Rafael
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
|Objectives.
To prospectively evaluate the technical feasibility and efficacy of wedged arterial injection (WAI) as a potential route for experimental selective therapy to the pancreas of healthy pigs.
Materials and Methods.
Selective angiographies were completed in ten pigs under general anaesthesia.
By superselective angiography, the catheter was inserted and wedged into the major pancreatic artery, blocking the blood flow.
In order to evaluate the efficacy of the WAI method, a DNA-specific fluorescent dye (Hoechst 33258) was used.
Results.
Histological study revealed a uniform distribution of the fluorescent dye within the nuclei of the endocrine and exocrine pancreatic cells.
Pancreatic and liver enzymes as well as histopathology of the pancreas were normal.
Conclusion.
WAI is a highly effective minimally invasive methodology to target the porcine pancreas.
The findings suggest that WAI may contribute to developing preclinical assays of pancreas gene or cell-transfer therapies in swine model.
American Psychological Association (APA)
Latorre, Rafael& Hernández, Wendy& Sun, Fei& Sánchez-Margallo, Francisco M.& Gil, Francisco& López-Albors, Octavio…[et al.]. 2011. Evaluation of Wedged Arterial Injection as a New Technique for Delivery of Experimental Therapeutic Sustances into the Porcine Pancreas. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990701
Modern Language Association (MLA)
Latorre, Rafael…[et al.]. Evaluation of Wedged Arterial Injection as a New Technique for Delivery of Experimental Therapeutic Sustances into the Porcine Pancreas. Journal of Diabetes Research No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-990701
American Medical Association (AMA)
Latorre, Rafael& Hernández, Wendy& Sun, Fei& Sánchez-Margallo, Francisco M.& Gil, Francisco& López-Albors, Octavio…[et al.]. Evaluation of Wedged Arterial Injection as a New Technique for Delivery of Experimental Therapeutic Sustances into the Porcine Pancreas. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990701