Recent Advance in Antigen-Specific Immunotherapy for Acute Myeloid Leukemia
Joint Authors
Kitawaki, Toshio
Kadowaki, Norimitsu
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Relapse after chemotherapy is inevitable in the majority of patients with acute myeloid leukemia (AML).
Thus, it is necessary to develop novel therapies that have different antileukemic mechanisms.
Recent advances in immunology and identification of promising leukemia-associated antigens open the possibilities for eradicating minimal residual diseases by antigen-specific immunotherapy after chemotherapy.
Several methods have been pursued as immunotherapies for AML: peptide vaccines, granulocyte-macrophage colony-stimulating factor-secreting tumor vaccines, dendritic cell vaccines, and adoptive T cell therapy.
Whereas immunogenicity and clinical outcomes are improving in these trials, severe adverse events were observed in highly avid engineered T cell therapies, indicating the importance of the balance between effectiveness and side effects in advanced immunotherapy.
Such progress in inducing antitumor immune responses, together with strategies to attenuate immunosuppressive factors, will establish immunotherapy as an important armament to combat AML.
American Psychological Association (APA)
Kadowaki, Norimitsu& Kitawaki, Toshio. 2011. Recent Advance in Antigen-Specific Immunotherapy for Acute Myeloid Leukemia. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990723
Modern Language Association (MLA)
Kadowaki, Norimitsu& Kitawaki, Toshio. Recent Advance in Antigen-Specific Immunotherapy for Acute Myeloid Leukemia. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-990723
American Medical Association (AMA)
Kadowaki, Norimitsu& Kitawaki, Toshio. Recent Advance in Antigen-Specific Immunotherapy for Acute Myeloid Leukemia. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990723