The Impact of Transcriptomics on the Fight against Tuberculosis: Focus on Biomarkers, BCG Vaccination, and Immunotherapy
Joint Authors
Passos, Geraldo A.
Zárate-Bladés, Carlos Rodrigo
Silva, Celio Lopes
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In 1882 Robert Koch identified Mycobacterium tuberculosis as the causative agent of tuberculosis (TB), a disease as ancient as humanity.
Although there has been more than 125 years of scientific effort aimed at understanding the disease, serious problems in TB persist that contribute to the estimated 1/3 of the world population infected with this pathogen.
Nonetheless, during the first decade of the 21st century, there were new advances in the fight against TB.
The development of high-throughput technologies is one of the major contributors to this advance, because it allows for a global vision of the biological phenomenon.
This paper analyzes how transcriptomics are supporting the translation of basic research into therapies by resolving three key issues in the fight against TB: (a) the discovery of biomarkers, (b) the explanation of the variability of protection conferred by BCG vaccination, and (c) the development of new immunotherapeutic strategies to treat TB.
American Psychological Association (APA)
Zárate-Bladés, Carlos Rodrigo& Silva, Celio Lopes& Passos, Geraldo A.. 2010. The Impact of Transcriptomics on the Fight against Tuberculosis: Focus on Biomarkers, BCG Vaccination, and Immunotherapy. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990731
Modern Language Association (MLA)
Zárate-Bladés, Carlos Rodrigo…[et al.]. The Impact of Transcriptomics on the Fight against Tuberculosis: Focus on Biomarkers, BCG Vaccination, and Immunotherapy. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-990731
American Medical Association (AMA)
Zárate-Bladés, Carlos Rodrigo& Silva, Celio Lopes& Passos, Geraldo A.. The Impact of Transcriptomics on the Fight against Tuberculosis: Focus on Biomarkers, BCG Vaccination, and Immunotherapy. Journal of Immunology Research. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990731