Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity
Joint Authors
Belz, Gabrielle T.
Rankin, Lucille
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The helix-loop-helix (HLH) transcription factor inhibitor of DNA binding 2 (Id2) has been implicated as a regulator of hematopoiesis and embryonic development.
While its role in early lymphopoiesis has been well characterized, new roles in adaptive immune responses have recently been uncovered opening exciting new directions for investigation.
In the innate immune system, Id2 is required for the development of mature natural killer (NK) cells, lymphoid tissue-inducer (LTi) cells, and the recently identified interleukin (IL)-22 secreting nonconventional innate lymphocytes found in the gut.
In addition, Id2 has been implicated in the development of specific dendritic cell (DC) subsets, decisions determining the formation of αβ and γδ T-cell development, NK T-cell behaviour, and in the maintenance of effector and memory CD8+ T cells in peripheral tissues.
Here, we review the current understanding of the role of Id2 in lymphopoiesis and in the development of the adaptive immune response required for maintaining immune homeostasis and immune protection.
American Psychological Association (APA)
Rankin, Lucille& Belz, Gabrielle T.. 2011. Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990740
Modern Language Association (MLA)
Rankin, Lucille& Belz, Gabrielle T.. Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-990740
American Medical Association (AMA)
Rankin, Lucille& Belz, Gabrielle T.. Diverse Roles of Inhibitor of Differentiation 2 in Adaptive Immunity. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990740