Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns
Joint Authors
Manguso, Francesco
Messina, Francesco
Terrin, Gianluca
Passariello, Annalisa
Rapacciuolo, Luciano
Salvia, Gennaro
Canani, Roberto Berni
Raimondi, Francesco
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
To determine the diagnostic utility of serum calprotectin, a mediator of innate immune response against infections, we performed a multicenter study involving newborns with a birth weight <1500 g and a postnatal age >72 hours of life.
The diagnostic accuracy of serum calprotectin was compared with that of the most commonly used markers of neonatal sepsis (white blood cell count, immature-to-total-neutrophil ratio, platelet count, and C-reactive protein).
We found that the serum calprotectin concentration was significantly higher (P<.001) in 62 newborns with confirmed sepsis (3.1±1.0 μg/mL) than in either 29 noninfected subjects (1.1±0.3 μg/ml) or 110 healthy controls (0.91±0.58 μg/ml).
The diagnostic accuracy of serum calprotectin was greater (sensitivity 89%, specificity 96%) than that of the traditional markers of sepsis.
In conclusion, serum calprotectin is an accurate marker of sepsis in very low birth weight newborns.
American Psychological Association (APA)
Terrin, Gianluca& Passariello, Annalisa& Manguso, Francesco& Salvia, Gennaro& Rapacciuolo, Luciano& Messina, Francesco…[et al.]. 2011. Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990746
Modern Language Association (MLA)
Terrin, Gianluca…[et al.]. Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-990746
American Medical Association (AMA)
Terrin, Gianluca& Passariello, Annalisa& Manguso, Francesco& Salvia, Gennaro& Rapacciuolo, Luciano& Messina, Francesco…[et al.]. Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990746