Mechanisms That Regulate Peripheral Immune Responses to Control Organ-Specific Autoimmunity
Author
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The immune system must balance the need to maintain a diverse repertoire of lymphocytes to be able to fight infection with the need to maintain tolerance to self-proteins.
The immune system places strict regulation over the ability of T cells to produce the major T cell growth factor interleukin 2 as this cytokine can influence a variety of immune outcomes.
T cells require the delivery of two signals, one through the antigen receptor and a second through the costimulatory receptor CD28.
The immune system uses a variety of E3 ubiquitin ligases to target signaling proteins that function downstream of the TCR and CD28 receptors.
Mutations in these E3 ligases can lead to a breakdown in immune tolerance and development of autoimmunity.
This paper will examine the role of a range of E3 ubiquitin ligases and signaling pathways that influence the development of T-cell effector responses and the development of organ-specific autoimmune diseases such as type 1 diabetes.
American Psychological Association (APA)
Hoyne, Gerard F.. 2011. Mechanisms That Regulate Peripheral Immune Responses to Control Organ-Specific Autoimmunity. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990747
Modern Language Association (MLA)
Hoyne, Gerard F.. Mechanisms That Regulate Peripheral Immune Responses to Control Organ-Specific Autoimmunity. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-990747
American Medical Association (AMA)
Hoyne, Gerard F.. Mechanisms That Regulate Peripheral Immune Responses to Control Organ-Specific Autoimmunity. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990747
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990747