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Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children
Joint Authors
Resende, Rafael O.
Taketomi, Ernesto A.
Silva, Deise Aparecida Oliveira
Segundo, Gesmar Rodrigues Silva
Fernandes, Jorge F. C.
Ynoue, Leandro Hideki
Miranda, Diego O.
Queirós, Meimei G. J.
Pena, Janethe D. O.
Chiba, Hamilton F.
Sung, Sun-Sang J.
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Allergic rhinitis (AR) is a public health problem with high prevalence worldwide.
We evaluated levels of specific IgE, IgA, and IgG4 antibodies to the Dermatophagoides pteronyssinus (Dpt) house dust mite and to its major allergens (Der p1 and Der p2) in serum and saliva samples from allergic and nonallergic children.
A total of 86 children were analyzed, from which 72 had AR and 14 were nonallergic healthy children.
Serum IgE and serum/salivary IgG4 levels to Dpt, Der p1, and Der p2 were higher in allergic children whereas serum/salivary IgA levels to all allergens were higher in nonallergic children.
IgE levels positively correlated with IgG4 and IgA to all allergens in allergic children, while IgA levels negatively correlated with IgG4 to Dpt and Der p1 in nonallergic children.
In conclusion, mite-specific IgA antibodies predominate in the serum and saliva of nonallergic children whereas mite-specific IgE and IgG4 are prevalent in allergic children.
The presence of specific IgA appears to have a key role for the healthy immune response to mucosal allergens.
Also, specific IgA measurements in serum and/or saliva may be useful for monitoring activation of tolerance-inducing mechanisms during allergen specific immunotherapeutic procedures, especially sublingual immunotherapy.
American Psychological Association (APA)
Miranda, Diego O.& Silva, Deise Aparecida Oliveira& Fernandes, Jorge F. C.& Queirós, Meimei G. J.& Chiba, Hamilton F.& Ynoue, Leandro Hideki…[et al.]. 2011. Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990749
Modern Language Association (MLA)
Miranda, Diego O.…[et al.]. Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-990749
American Medical Association (AMA)
Miranda, Diego O.& Silva, Deise Aparecida Oliveira& Fernandes, Jorge F. C.& Queirós, Meimei G. J.& Chiba, Hamilton F.& Ynoue, Leandro Hideki…[et al.]. Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990749