Role of IL-17 and Th17 Cells in Liver Diseases
Joint Authors
Heymann, Felix
Tacke, Frank
Hammerich, Linda
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Unbalanced Th1/Th2 T-cell responses in the liver are a characteristic of hepatic inflammation and subsequent liver fibrosis.
The recently discovered Th17 cells, a subtype of CD4+ T-helper cells mainly producing IL-17 and IL-22, have initially been linked to host defense against infections and to autoimmunity.
Their preferred differentiation upon TGFβ and IL-6, two cytokines abundantly present in injured liver, makes a contribution of Th17 cells to hepatic inflammation very likely.
Indeed, initial studies in humans revealed activated Th17 cells and Th17-related cytokines in various liver diseases.
However, functional experiments in mouse models are not fully conclusive at present, and the pathogenic contribution of Th17 cells to liver inflammation might vary upon the disease etiology, for example, between infectious and autoimmune disorders.
Understanding the chemokines and chemokine receptors promoting hepatic Th17 cell recruitment (possibly CCR6 or CCR4) might reveal new therapeutic targets interfering with Th17 migration or differentiation in liver disease.
American Psychological Association (APA)
Hammerich, Linda& Heymann, Felix& Tacke, Frank. 2010. Role of IL-17 and Th17 Cells in Liver Diseases. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990755
Modern Language Association (MLA)
Hammerich, Linda…[et al.]. Role of IL-17 and Th17 Cells in Liver Diseases. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-990755
American Medical Association (AMA)
Hammerich, Linda& Heymann, Felix& Tacke, Frank. Role of IL-17 and Th17 Cells in Liver Diseases. Journal of Immunology Research. 2010. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990755