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Clustering of Mycobacterium tuberculosis Cases in Acapulco: Spoligotyping and Risk Factors
Joint Authors
Mitchell, Steven
Nava-Aguilera, Elizabeth
Villegas-Arrizón, Ascencio
Harris, Eva
Andersson, Neil
Ledogar, Robert
Legorreta-Soberanis, José
Morales-Pérez, Arcadio
López-Vidal, Yolanda
Flores-Moreno, Miguel
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Recurrence and reinfection of tuberculosis have quite different implications for prevention.
We identified 267 spoligotypes of Mycobacterium tuberculosis from consecutive tuberculosis patients in Acapulco, Mexico, to assess the level of clustering and risk factors for clustered strains.
Point cluster analysis examined spatial clustering.
Risk analysis relied on the Mantel Haenszel procedure to examine bivariate associations, then to develop risk profiles of combinations of risk factors.
Supplementary analysis of the spoligotyping data used SpolTools.
Spoligotyping identified 85 types, 50 of them previously unreported.
The five most common spoligotypes accounted for 55% of tuberculosis cases.
One cluster of 70 patients (26% of the series) produced a single spoligotype from the Manila Family (Clade EAI2).
The high proportion (78%) of patients infected with cluster strains is compatible with recent transmission of TB in Acapulco.
Geomatic analysis showed no spatial clustering; clustering was associated with a risk profile of uneducated cases who lived in single-room dwellings.
The Manila emerging strain accounted for one in every four cases, confirming that one strain can predominate in a hyperendemic area.
American Psychological Association (APA)
Nava-Aguilera, Elizabeth& López-Vidal, Yolanda& Harris, Eva& Morales-Pérez, Arcadio& Mitchell, Steven& Flores-Moreno, Miguel…[et al.]. 2010. Clustering of Mycobacterium tuberculosis Cases in Acapulco: Spoligotyping and Risk Factors. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990786
Modern Language Association (MLA)
Nava-Aguilera, Elizabeth…[et al.]. Clustering of Mycobacterium tuberculosis Cases in Acapulco: Spoligotyping and Risk Factors. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-990786
American Medical Association (AMA)
Nava-Aguilera, Elizabeth& López-Vidal, Yolanda& Harris, Eva& Morales-Pérez, Arcadio& Mitchell, Steven& Flores-Moreno, Miguel…[et al.]. Clustering of Mycobacterium tuberculosis Cases in Acapulco: Spoligotyping and Risk Factors. Journal of Immunology Research. 2010. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990786