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T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives
Joint Authors
Mallone, Roberto
Brezar, Vedran
Boitard, Christian
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Type 1 diabetes (T1D) is an autoimmune disease driven by the activation of lymphocytes against pancreatic β-cells.
Among β-cell autoantigens, preproinsulin has been ascribed a key role in the T1D process.
The successive steps that control the activation of autoreactive lymphocytes have been extensively studied in animal models of T1D, but remains ill defined in man.
In man, T lymphocytes, especially CD8+ T cells, are predominant within insulitis.
Developing T-cell assays in diabetes autoimmunity is, thus, a major challenge.
It is expected to help defining autoantigens and epitopes that drive the disease process, to pinpoint key functional features of epitope-specific T lymphocytes along the natural history of diabetes and to pave the way towards therapeutic strategies to induce immune tolerance to β-cells.
New T-cell technologies will allow defining autoreactive T-cell differentiation programs and characterizing autoimmune responses in comparison with physiologically appropriate immune responses.
This may prove instrumental in the discovery of immune correlates of efficacy in clinical trials.
American Psychological Association (APA)
Mallone, Roberto& Brezar, Vedran& Boitard, Christian. 2011. T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-990805
Modern Language Association (MLA)
Mallone, Roberto…[et al.]. T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-16.
https://search.emarefa.net/detail/BIM-990805
American Medical Association (AMA)
Mallone, Roberto& Brezar, Vedran& Boitard, Christian. T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-990805
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990805