Newborn Mice Vaccination with BCG.HIVA222 + MVA.HIVA Enhances HIV-1-Specific Immune Responses: Influence of Age and Immunization Routes
Joint Authors
Hanke, Tomáš
Fernández-Lloris, Raquel
Gatell, Josep Maria
Cardona, Pere-Joan
Joseph, Joan
Saubi, Narcís
Gil, Olga
Im, Eung-Jun
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We have evaluated the influence of age and immunization routes for induction of HIV-1- and M.
tuberculosis-specific immune responses after neonatal (7 days old) and adult (7 weeks old) BALB/c mice immunization with BCG.HIVA222 prime and MVA.HIVA boost.
The specific HIV-1 cellular immune responses were analyzed in spleen cells.
The body weight of the newborn mice was weekly recorded.
The frequencies of HIV-specific CD8+ T cells producing IFN-γ were higher in adult mice vaccinated intradermally and lower in adult and newborn mice vaccinated subcutaneously.
In all cases the IFN-γ production was significantly higher when mice were primed with BCG.HIVA222 compared with BCGwt.
When the HIV-specific CTL activity was assessed, the frequencies of specific killing were higher in newborn mice than in adults.
The prime-boost vaccination regimen which includes BCG.HIVA222 and MVA.HIVA was safe when inoculated to newborn mice.
The administration of BCG.HIVA222 to newborn mice is safe and immunogenic and increased the HIV-specific responses induced by MVA.HIVA vaccine.
It might be a good model for infant HIV and Tuberculosis bivalent vaccine.
American Psychological Association (APA)
Saubi, Narcís& Im, Eung-Jun& Fernández-Lloris, Raquel& Gil, Olga& Cardona, Pere-Joan& Gatell, Josep Maria…[et al.]. 2011. Newborn Mice Vaccination with BCG.HIVA222 + MVA.HIVA Enhances HIV-1-Specific Immune Responses: Influence of Age and Immunization Routes. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990806
Modern Language Association (MLA)
Saubi, Narcís…[et al.]. Newborn Mice Vaccination with BCG.HIVA222 + MVA.HIVA Enhances HIV-1-Specific Immune Responses: Influence of Age and Immunization Routes. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-990806
American Medical Association (AMA)
Saubi, Narcís& Im, Eung-Jun& Fernández-Lloris, Raquel& Gil, Olga& Cardona, Pere-Joan& Gatell, Josep Maria…[et al.]. Newborn Mice Vaccination with BCG.HIVA222 + MVA.HIVA Enhances HIV-1-Specific Immune Responses: Influence of Age and Immunization Routes. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990806