Oxidative Stress and Redox Modulation Potential in Type 1 Diabetes
Joint Authors
Delmastro, Meghan M.
Piganelli, Jon D.
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-18
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Redox reactions are imperative to preserving cellular metabolism yet must be strictly regulated.
Imbalances between reactive oxygen species (ROS) and antioxidants can initiate oxidative stress, which without proper resolve, can manifest into disease.
In type 1 diabetes (T1D), T-cell-mediated autoimmune destruction of pancreatic β-cells is secondary to the primary invasion of macrophages and dendritic cells (DCs) into the islets.
Macrophages/DCs, however, are activated by intercellular ROS from resident pancreatic phagocytes and intracellular ROS formed after receptor-ligand interactions via redox-dependent transcription factors such as NF-κB.
Activated macrophages/DCs ferry β-cell antigens specifically to pancreatic lymph nodes, where they trigger reactive T cells through synapse formation and secretion of proinflammatory cytokines and more ROS.
ROS generation, therefore, is pivotal in formulating both innate and adaptive immune responses accountable for islet cell autoimmunity.
The importance of ROS/oxidative stress as well as potential for redox modulation in the context of T1D will be discussed.
American Psychological Association (APA)
Delmastro, Meghan M.& Piganelli, Jon D.. 2011. Oxidative Stress and Redox Modulation Potential in Type 1 Diabetes. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-990815
Modern Language Association (MLA)
Delmastro, Meghan M.& Piganelli, Jon D.. Oxidative Stress and Redox Modulation Potential in Type 1 Diabetes. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-15.
https://search.emarefa.net/detail/BIM-990815
American Medical Association (AMA)
Delmastro, Meghan M.& Piganelli, Jon D.. Oxidative Stress and Redox Modulation Potential in Type 1 Diabetes. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-990815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990815