Pathological Role of Tonsillar B Cells in IgA Nephropathy
Joint Authors
Nakata, Junichiro
Kajiyama, Tadahiro
Tomino, Yasuhiko
Sato, Daisuke
Watanabe, Tomonari
Suzuki, Yusuke
Suzuki, Hitoshi
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Although impaired immune regulation along the mucosa-bone marrow axis has been postulated to play an important role, the pathogenesis of IgA nephropathy (IgAN) is unknown; thus, no disease-specific therapy for this disease exists.
The therapeutic efficacy of tonsillectomy or tonsillectomy in combination with steroid pulse therapy for IgAN has been discussed.
Although randomized control trials for these therapies are ongoing in Japan, the scientific rationale for these therapies remains obscure.
It is now widely accepted that abnormally glycosylated IgA1 and its related immune complex (IC) are probably key molecules for the pathogenesis, and are thus considered possible noninvasive biomarkers for this disease.
Emerging evidence indicates that B cells in mucosal infections, particularly in tonsillitis, may produce the nephritogenic IgA.
In this paper, we briefly summarize characteristics of the nephritogenic IgA/IgA IC, responsible B cells, and underlying mechanisms.
This clinical and experimental information may provide important clues for a therapeutic rationale.
American Psychological Association (APA)
Suzuki, Yusuke& Suzuki, Hitoshi& Nakata, Junichiro& Sato, Daisuke& Kajiyama, Tadahiro& Watanabe, Tomonari…[et al.]. 2011. Pathological Role of Tonsillar B Cells in IgA Nephropathy. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990833
Modern Language Association (MLA)
Suzuki, Yusuke…[et al.]. Pathological Role of Tonsillar B Cells in IgA Nephropathy. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-990833
American Medical Association (AMA)
Suzuki, Yusuke& Suzuki, Hitoshi& Nakata, Junichiro& Sato, Daisuke& Kajiyama, Tadahiro& Watanabe, Tomonari…[et al.]. Pathological Role of Tonsillar B Cells in IgA Nephropathy. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990833