Behçet's Disease (Adamantiades-Behçet's Disease)
Joint Authors
Oguma, Keiji
Sakuma, Hideo
Yokota, Kenji
Kaneko, Fumio
Saito, Sanae
Nakamura, Koichiro
Togashi, Ari
Oyama, Noritaka
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Adamantiades-Behçet's disease (ABD) is characterized by starting with oral aphthous ulceration and developing of the systemic involvements.
The pathogenesis of ABD is closely correlated with the genetic factors and the triggering factors which acquire delayed-type hypersensitivity reaction against oral streptococci mediated by IL-12 cytokine family.
HLA-B51 is associated in more than 60% of the patients and its restricted CD8+ T cell response is clearly correlated with the target tissues.
Bes-1 gene encoded partial S.
sanguinis genome which is highly homologous with retinal protein, and 65 kD heat shock protein (Hsp-65) released from streptococci is playing an important role with human Hsp-60 in the pathogenesis of ABD.
Although Hsp-65/60 has homologies with the respective T cell epitope, it stimulates peripheral blood mononuclear cells (PBMCs) from ABD patients.
On the other hand, some peptides of Hsp-65 were found to reduce IL-8 and IL-12 production from PBMCs of ABD patients in active stage.
American Psychological Association (APA)
Kaneko, Fumio& Togashi, Ari& Saito, Sanae& Sakuma, Hideo& Oyama, Noritaka& Nakamura, Koichiro…[et al.]. 2010. Behçet's Disease (Adamantiades-Behçet's Disease). Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990844
Modern Language Association (MLA)
Kaneko, Fumio…[et al.]. Behçet's Disease (Adamantiades-Behçet's Disease). Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-990844
American Medical Association (AMA)
Kaneko, Fumio& Togashi, Ari& Saito, Sanae& Sakuma, Hideo& Oyama, Noritaka& Nakamura, Koichiro…[et al.]. Behçet's Disease (Adamantiades-Behçet's Disease). Journal of Immunology Research. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990844