The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and Survival
Joint Authors
He, Changjun
Jiang, Hongchi
Sun, Xueying
Qiao, Haiquan
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
B7-H4 is one of the most recently identified members of B7 superfamily of costimulatory molecules serving as an inhibitory modulator of T-cell response.
B7-H4 is broadly expressed in human peripheral tissues and inducibly expressed in immune cells.
The expression of B7-H4 has been observed in various types of human cancer tissues, and its soluble form has been detected in blood samples from cancer patients.
However, its precise physiological role is still elusive, as its receptor has not been identified and the expression levels are not consistent.
This paper summarizes the pertinent data on the inhibitory role of B7-H4 in antitumor immunity and its association with cancer progression and survival in human patients.
The paper also discusses the clinical significance of investigating B7-H4 as potential markers for cancer diagnosis and prognosis, and as therapeutic targets.
American Psychological Association (APA)
He, Changjun& Qiao, Haiquan& Jiang, Hongchi& Sun, Xueying. 2011. The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and Survival. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990848
Modern Language Association (MLA)
He, Changjun…[et al.]. The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and Survival. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-990848
American Medical Association (AMA)
He, Changjun& Qiao, Haiquan& Jiang, Hongchi& Sun, Xueying. The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and Survival. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990848