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Antitumor Immunity Produced by the Liver Kupffer Cells, NK Cells, NKT Cells, and CD8+ CD122+ T Cells
Joint Authors
Kinoshita, Manabu
Nakashima, Masahiro
Seki, Shuhji
Nakashima, Hiroyuki
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mouse and human livers contain innate immune leukocytes, NK cells, NKT cells, and macrophage-lineage Kupffer cells.
Various bacterial components, including Toll-like receptor (TLR) ligands and an NKT cell ligand (α-galactocylceramide), activate liver Kupffer cells, which produce IL-1, IL-6, IL-12, and TNF.
IL-12 activates hepatic NK cells and NKT cells to produce IFN-γ, which further activates hepatic T cells, in turn activating phagocytosis and cytokine production by Kupffer cells in a positive feedback loop.
These immunological events are essentially evoked to protect the host from bacterial and viral infections; however, these events also contribute to antitumor and antimetastatic immunity in the liver by activated liver NK cells and NKT cells.
Bystander CD8+CD122+ T cells, and tumor-specific memory CD8+T cells, are also induced in the liver by α-galactocylceramide.
Furthermore, adoptive transfer experiments have revealed that activated liver lymphocytes may migrate to other organs to inhibit tumor growth, such as the lungs and kidneys.
The immunological mechanism underlying the development of hepatocellular carcinoma in cirrhotic livers in hepatitis C patients and liver innate immunity as a double-edged sword (hepatocyte injury/regeneration, septic shock, autoimmune disease, etc.) are also discussed.
American Psychological Association (APA)
Seki, Shuhji& Nakashima, Hiroyuki& Nakashima, Masahiro& Kinoshita, Manabu. 2011. Antitumor Immunity Produced by the Liver Kupffer Cells, NK Cells, NKT Cells, and CD8+ CD122+ T Cells. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990873
Modern Language Association (MLA)
Seki, Shuhji…[et al.]. Antitumor Immunity Produced by the Liver Kupffer Cells, NK Cells, NKT Cells, and CD8+ CD122+ T Cells. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-990873
American Medical Association (AMA)
Seki, Shuhji& Nakashima, Hiroyuki& Nakashima, Masahiro& Kinoshita, Manabu. Antitumor Immunity Produced by the Liver Kupffer Cells, NK Cells, NKT Cells, and CD8+ CD122+ T Cells. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990873