Monoclonal Antibodies in Gynecological Cancer: A Critical Point of View
Joint Authors
Zizzari, Ilaria Grazia
Bellati, Filippo
Ruscito, Ilary
Caccetta, Jlenia
Visconti, Valeria
Napoletano, Chiara
Gasparri, Maria Luisa
Rughetti, Aurelia
Benedetti-Panici, Pierluigi
Nuti, Marianna
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
During the last decades, several improvements in treating gynecological malignancies have been achieved.
In particular, target therapies, mostly monoclonal antibodies, have emerged as an attractive option for the treatment of these malignancies.
In fact, various molecular-targeted agents have been developed for a variety of malignancies with the objective to interfere with a precise tumor associated receptor, essential for cancer cell survival or proliferation, blocking its function, of the cancer cells.
Alternatively, monoclonal antibodies have been developed to block immune suppression or enhance functions of immune effector cells.
So far, several monoclonal antibodies have been tested for clinical efficacy for the treatment of gynecological cancers.
Antibodies against Vascular Endothelial Growth Factor (VEGF) and Epidermal Growth Factor Receptor (EGFR) have been used in different neoplasms such as ovarian and cervical cancer.
Catumazumab, a bivalent antibody against CD3 and EpCAM, is effective in the treatment of neoplastic ascites.
Other antibodies are peculiar for specific cancer-associated antigen such as Oregovomab against CA125 or Farletuzumab against the folate receptor.
Here we describe the preclinical and clinical experience gained up to now with monoclonal antibodies in tumors of the female genital tract and trace future therapeutic and research venues.
American Psychological Association (APA)
Bellati, Filippo& Napoletano, Chiara& Gasparri, Maria Luisa& Visconti, Valeria& Zizzari, Ilaria Grazia& Ruscito, Ilary…[et al.]. 2011. Monoclonal Antibodies in Gynecological Cancer: A Critical Point of View. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-990874
Modern Language Association (MLA)
Bellati, Filippo…[et al.]. Monoclonal Antibodies in Gynecological Cancer: A Critical Point of View. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-16.
https://search.emarefa.net/detail/BIM-990874
American Medical Association (AMA)
Bellati, Filippo& Napoletano, Chiara& Gasparri, Maria Luisa& Visconti, Valeria& Zizzari, Ilaria Grazia& Ruscito, Ilary…[et al.]. Monoclonal Antibodies in Gynecological Cancer: A Critical Point of View. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-990874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990874