Immune Dysregulation after Cardiothoracic Surgery and Incidental Thymectomy: Maintenance of Regulatory T Cells despite Impaired Thymopoiesis
Joint Authors
Boechat, M. Ines
Halnon, Nancy J.
Cooper, Paige
Chen, Diana Yu Hui
Uittenbogaart, Christel H.
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Thymectomy is performed in infants during cardiothoracic surgery leaving many patients with reduced thympopoiesis.
An association between immune disorders and regulatory T cells (Treg) after incidental thymectomy has not been investigated.
Questionnaires soliciting symptoms of atopic or autoimmune disease and biomarkers were measured in children and adults with congenital heart disease and either reduced or preserved thymopoiesis.
Tregs were examined.
Atopic or autoimmune-like symptoms and elevated anti-dsDNA antibodies were common after surgery in individuals with low thymopoiesis.
Total Treg number and function were maintained but with fewer naïve Treg.
TCR spectratypes were similar to other memory T cells.
These data suggest that thymectomy does not reduce total Treg number but homeostasis is affected with reduced naïve Treg.
Prevalence of autoimmune or atopic symptoms after surgery is not associated with total number or proportion of Tregs but appears to be due to otherwise unknown factors that may include altered Treg homeostasis.
American Psychological Association (APA)
Halnon, Nancy J.& Cooper, Paige& Chen, Diana Yu Hui& Boechat, M. Ines& Uittenbogaart, Christel H.. 2011. Immune Dysregulation after Cardiothoracic Surgery and Incidental Thymectomy: Maintenance of Regulatory T Cells despite Impaired Thymopoiesis. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990876
Modern Language Association (MLA)
Halnon, Nancy J.…[et al.]. Immune Dysregulation after Cardiothoracic Surgery and Incidental Thymectomy: Maintenance of Regulatory T Cells despite Impaired Thymopoiesis. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-990876
American Medical Association (AMA)
Halnon, Nancy J.& Cooper, Paige& Chen, Diana Yu Hui& Boechat, M. Ines& Uittenbogaart, Christel H.. Immune Dysregulation after Cardiothoracic Surgery and Incidental Thymectomy: Maintenance of Regulatory T Cells despite Impaired Thymopoiesis. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990876
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990876