Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B
Joint Authors
Li, Ming
Wang, Li-hua
Wu, Jian-hong
Luo, Xiang-rong
Zhang, Xue-hua
Zhu, Chuan-wu
Wang, Hai-yan
Zhu, Wei
Chen, Ming
Qian, Feng
Ye, Jian-zhong
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cell division is closely related to telomerase activity (hTERT mRNA).
Lower expression of lymphocitic hTERT mRNA may easily cause cell aging, which is not beneficial to maintaining a durable lymphocyte division.
To date, there is no study to investigate IFNα therapy on hTERT mRNA expression in PBMCs of patients with chronic hepatitis B (CHB).
We quantitatively detected hTERT mRNA from study subjects and made each hTERT mRNA normalized (NhTERT mRNA).
Mean NhTERT mRNA level was lower in either CHB group, but it significantly increased in IFNα-treated group compared with CHB control group, and a longer duration of IFNα therapy could increase the level.
Moreover, the mean NhTERT mRNA in subgroup with HBeAg loss was significantly higher than that in subgroup without.
NhTERT mRNA was markedly correlated with CD3+ T lymphocyte count and CD4+/CD8+ ratio.
The results showed that IFNα therapy could upregulate the expression of hTERT mRNA in PBMCs.
American Psychological Association (APA)
Zhu, Chuan-wu& Chen, Ming& Luo, Xiang-rong& Wang, Hai-yan& Wang, Li-hua& Wu, Jian-hong…[et al.]. 2011. Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990878
Modern Language Association (MLA)
Zhu, Chuan-wu…[et al.]. Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-990878
American Medical Association (AMA)
Zhu, Chuan-wu& Chen, Ming& Luo, Xiang-rong& Wang, Hai-yan& Wang, Li-hua& Wu, Jian-hong…[et al.]. Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990878