PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors
Joint Authors
Dituri, Francesco
Mazzocca, Antonio
Giannelli, Gianluigi
Antonaci, Salvatore
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The immunological surveillance of tumors relies on a specific recognition of cancer cells and their associate antigens by leucocytes of innate and adaptive immune responses.
However, a dysregulated cytokine release can lead to, or be associated with, a failure in cell-cell recognition, thus, allowing cancer cells to evade the killing system.
The phosphatidylinositol 3-kinase (PI3K) pathway regulates multiple cellular processes which underlie immune responses against pathogens or malignant cells.
Conversely, there is accumulating evidence that the PI3K pathway is involved in the development of several malignant traits of cancer cells as well as their escape from immunity.
Herein, we review the counteracting roles of PI3K not only in antitumor immune response but also in the mechanisms that cancer cells use to avoid leukocyte attack.
In addition, we discuss, from antitumor immunological point of view, the potential benefits and disadvantages arising from use of anticancer pharmacological agents targeting the PI3K pathway.
American Psychological Association (APA)
Dituri, Francesco& Mazzocca, Antonio& Giannelli, Gianluigi& Antonaci, Salvatore. 2011. PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990879
Modern Language Association (MLA)
Dituri, Francesco…[et al.]. PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-990879
American Medical Association (AMA)
Dituri, Francesco& Mazzocca, Antonio& Giannelli, Gianluigi& Antonaci, Salvatore. PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990879