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Control of Aptamer Function Using Radiofrequency Magnetic Field
Joint Authors
Taira, Kenichi
Abe, Koichi
Ishibasi, Takayuki
Sato, Katsuaki
Ikebukuro, Kazunori
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Remote control of aptamer function has allowed us to control protein function in space and time.
Here, we propose a novel control system for aptamer function by radiofrequency magnetic field- (RFMF-) induced local heating of a gold nanoparticle conjugated with an aptamer.
In this study, we used a 31-mer thrombin-binding aptamer (TBA), which can inhibit thrombin activity, as a model aptamer.
We evaluated the RFMF control of the inhibitory activity of a gold nanoparticle-conjugated TBA.
To evaluate the effect of RFMF on enzymatic activity, we utilized a complementary DNA strand that maintains the broken structure during the activity assay.
We observed a decrease in the inhibitory activity of TBA after RFMF irradiation.
It indicates that RFMF is capable of controlling the TBA structure.
Because RFMF allows noninvasive control of aptamer function, this strategy is expected to be novel way of controlling aptamer drug activity.
American Psychological Association (APA)
Taira, Kenichi& Abe, Koichi& Ishibasi, Takayuki& Sato, Katsuaki& Ikebukuro, Kazunori. 2011. Control of Aptamer Function Using Radiofrequency Magnetic Field. Journal of Nucleic Acids،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990964
Modern Language Association (MLA)
Taira, Kenichi…[et al.]. Control of Aptamer Function Using Radiofrequency Magnetic Field. Journal of Nucleic Acids No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-990964
American Medical Association (AMA)
Taira, Kenichi& Abe, Koichi& Ishibasi, Takayuki& Sato, Katsuaki& Ikebukuro, Kazunori. Control of Aptamer Function Using Radiofrequency Magnetic Field. Journal of Nucleic Acids. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990964