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Corpus Callosum Microstructural Changes Correlate with Cognitive Dysfunction in Early Stages of Relapsing-Remitting Multiple Sclerosis: Axial and Radial Diffusivities Approach
Joint Authors
Rimkus, Carolina de Medeiros
Junqueira, Thiago de Faria
Lyra, Katarina Paz
Jackowski, Marcel P.
Machado, Melissa A. R.
Miotto, Eliane C.
Callegaro, Dagoberto
Otaduy, Maria Concepción García
Leite, Claudia da Costa
Source
Multiple Sclerosis International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The corpus callosum is the largest fiber bundle in the central nervous system and it takes part in several cognitive pathways.
It can be affected by multiple sclerosis (MS) early in the disease.
DTI is capable of infering the microstructural organization of the white matter.
The vectorial analysis of the DTI offers the more specific indices of axial diffusivity (AD) and radial diffusivity (RD), which have shown to be useful to discriminate myelin damage from axon loss, respectively.
This study presents DTI results (mean diffusivity (MD), fractional anisotropy (FA), RD, and AD) of 23 relapsing-remitting MS patients and its correlation with cognitive performance.
There were 47.8% of cognitive impaired patients (MS CI).
We found signs of demyelination, reflected by increased RD, and incipient axon loss, reflected by AD increase, which was slightly higher in the MS CI.
The cognitive changes correlated with the DTI parameters, suggesting that loss of complexity in CC connections can impair neural conduction.
Thus, cognitive impairment can be related to callosal disconnection, and DTI can be a promising tool to evaluate those changes.
American Psychological Association (APA)
Rimkus, Carolina de Medeiros& Junqueira, Thiago de Faria& Lyra, Katarina Paz& Jackowski, Marcel P.& Machado, Melissa A. R.& Miotto, Eliane C.…[et al.]. 2011. Corpus Callosum Microstructural Changes Correlate with Cognitive Dysfunction in Early Stages of Relapsing-Remitting Multiple Sclerosis: Axial and Radial Diffusivities Approach. Multiple Sclerosis International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990970
Modern Language Association (MLA)
Rimkus, Carolina de Medeiros…[et al.]. Corpus Callosum Microstructural Changes Correlate with Cognitive Dysfunction in Early Stages of Relapsing-Remitting Multiple Sclerosis: Axial and Radial Diffusivities Approach. Multiple Sclerosis International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-990970
American Medical Association (AMA)
Rimkus, Carolina de Medeiros& Junqueira, Thiago de Faria& Lyra, Katarina Paz& Jackowski, Marcel P.& Machado, Melissa A. R.& Miotto, Eliane C.…[et al.]. Corpus Callosum Microstructural Changes Correlate with Cognitive Dysfunction in Early Stages of Relapsing-Remitting Multiple Sclerosis: Axial and Radial Diffusivities Approach. Multiple Sclerosis International. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990970